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Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone is used in so many conditions, only the most common or established uses are mentioned here. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Corticosteroids, including prednisone, are commonly used to suppress the immune system. If you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Deltasone is used in so many conditions, only the most common or established uses are mentioned here. You have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone. It easier for you to get an infection. Prednisolone is used for treating leukemia, lymphomas and autoimmune hemolytic anemia.