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Prednisone typically does not produce immediate effects and must be used for several days before the needed effect is achieved. Prednisone to Prednisolone is impaired. Prednisone and Prednisolone are considered to be intermediate acting steroids, meaning that a dose lasts about a day or a day and a half. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. Your immune system, making it easier for you to get an infection. Corticosteroids produced naturally by the body. Prednisolone is a corticosteroid medicine. If you have any of these conditions, you may need a dose adjustment or special tests to safely take Prednisolone. You may need a dose adjustment or special tests to safely take Prednisolone.