Fluconazole increases the concentration of Celecoxib in the liver. Celecoxib is a nonsteroidal anti-inflammatory drug that is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus. If you are already taking Celebrex, use the lowest dose possible for the shortest possible time necessary to relieve your symptoms. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver.
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