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Take Keflex at even intervals around the clock as prescribed by your doctor. Keflex can be used as first-line therapy for MRSA infections and is the most prescribed oral cephalosporin medicine. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Take additional cephalosporin antibiotics as this is likely to result in an overdose. Take Keflex at even intervals around the clock as prescribed by your doctor. Although side effects from Cephalexin are not common, they can occur. This medication. The growth of micro-organisms such as bacteria, fungi, or protozoa. The effects of Cephalexin.